dc.contributor.author |
Patton, Jennie |
en_US |
dc.date.accessioned |
2013-12-16T18:58:41Z |
|
dc.date.accessioned |
2019-09-08T02:36:06Z |
|
dc.date.available |
2013-12-16T18:58:41Z |
|
dc.date.available |
2019-09-08T02:36:06Z |
|
dc.date.issued |
2008 |
|
dc.identifier |
265034479 |
en_US |
dc.identifier.other |
b20345859 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/10797 |
|
dc.description |
x, 160 leaves : ill. ; 29 cm. |
en_US |
dc.description.abstract |
The following describes a successful synthetic pathway to create an analog of the natural product (+)-dihydrocanadensolide from the inexpensive and readily available D-xylose. The pathway will describe protecting group chemistry, an esterification, a diazo transfer reaction, and the key step being a metal-catalyzed intramolecular insertion reaction. The metal catalyst used in this step is rhodium(II) acetate and it will be shown to catalyze the decomposition of a diazoester, thus creating a new carbon-carbon bond by carbenoid insertion chemistry. The end result is a bicyclic compound with a fused furan ring system common to many important and useful natural products. |
en_US |
dc.description.statementofresponsibility |
by Jennie L. Patton. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 1113 |
en_US |
dc.subject.lcsh |
Carbohydrates--Synthesis. |
en_US |
dc.subject.lcsh |
Saccharides. |
en_US |
dc.subject.lcsh |
Natural products. |
en_US |
dc.subject.lcsh |
Chemistry, Organic. |
en_US |
dc.title |
Carbenoid Insertion Chemistry on Furanose Platforms as a Route to Natural Product Frameworks |
en_US |
dc.type |
Thesis |
en_US |