Abstract:
The following piece of work describes the synthesis of N-acety-L-fucosamine (L-FucNAc) and related novel N-glycosides to serve as glycomimetics for the inhibition of Staphylococcus aureus capsular polysaccharide biosynthesis. N-glycosyl amides were made via a modified Staudinger reaction while 1, 4-disubstituted-1,2,3-triazoles were synthesized using 1,3-dipolar cycloaddition of azides to alkynes in the presence of Cu(I) catalyst generated in situ as a a reaction between CuSO4 and Vitamin C.
Description:
xiv, 344 leaves : ill. ; 29 cm.
Thesis (M.S.)--Youngstown State University, 2006.
Includes bibliographical references (leaves 119-124).