Facile preparation of glycomimetics from uronic acids

Smith, Craig Richard

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dc.contributor.author	Smith, Craig Richard
dc.contributor.other	Youngstown State University. Department of Chemistry.
dc.date.accessioned	2021-10-14T16:59:35Z
dc.date.available	2021-10-14T16:59:35Z
dc.date.issued	2005
dc.identifier.other	B19736393
dc.identifier.other	61770128
dc.identifier.uri	https://jupiter.ysu.edu:443/record=b1973639
dc.identifier.uri	http://hdl.handle.net/1989/16621
dc.description	xvi, 362 leaves : ill. ; 29 cm. Thesis (M.S.)--Youngstown State University, 2005. Includes bibliographical references (leaves 122-129).	en_US
dc.description.abstract	The following work describes facile methods for the preparation of amino sugar analogs of N-acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManAcA). Two main approaches were investigated in the synthesis of N-glycosides. Staudinger and aza-Wittig approaches were used to synthesize glucosyl amides and imines. Another approach to the synthesis of N-glycosides involved the application of 1,3-dipolarcycloadditions of azides and alkynes in the presence of a Cu(I) catalyst. The synthesis of O-glycosides and C-glycosides of the methyl ester of glucuronic acid were studied in regard to the development of high yielding, stereospecific mimetic syntheses.	en_US
dc.description.sponsorship	Youngstown State University. Department of Chemistry.	en_US
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	Master's Theses;no. 0871
dc.subject	Glycosides -- Synthesis.	en_US
dc.subject	Uronic acids.	en_US
dc.subject	Amino sugars.	en_US
dc.title	Facile preparation of glycomimetics from uronic acids	en_US
dc.type	Thesis	en_US

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