dc.contributor.author |
Watkins, Thomas C. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Biology. |
en_US |
dc.date.accessioned |
2011-01-31T14:16:26Z |
|
dc.date.accessioned |
2019-09-08T02:30:55Z |
|
dc.date.available |
2011-01-31T14:16:26Z |
|
dc.date.available |
2019-09-08T02:30:55Z |
|
dc.date.created |
1998 |
en_US |
dc.date.issued |
1998 |
en_US |
dc.identifier.other |
b18242479 |
en_US |
dc.identifier.uri |
http://www.ohiolink.edu/etd/view.cgi?ysu997728299 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1824247 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6076 |
|
dc.description |
vii,79 leaves : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 1998. |
en_US |
dc.description |
Includes bibliographical references (leaves ). |
en_US |
dc.description.abstract |
Rippling muscle disease has been previously described by Torbergsen,
as a rare autosomal dominant condition characterized by: muscle stiffness
after resting, localized mounding ofmuscle after resting and electrically
silent wave like contractions after stretching (Le. rippling muscles). In 1990
Ansevin described a patient displaying electrically silent rippling muscles
with no evidence ofMyasthenia gravis. In 1995 the patient returned for
treatment for myasthenia gravis (MG). At the time oftreatment for MG the
rippling muscles were absent. It was theorized that the rippling muscles, in
this patient, were the result of an autoimmune condition related to the one
that brought on the MG. We have examined serum obtained from this
patient with active rippling symptoms and when the rippling symptoms had
abated, by western blotting. We have also examined serum obtained from
two other patients with rippling muscles and MG. Results indicate that high
and intermediate molecular weight antigens in skeletal muscle are
recognized by autoantibodies in patients with rippling muscles, which are
not present in patients with myasthenia gravis alone. The data suggest
autoantibodies may be binding to stretch activated channel proteins causing
the symptoms of rippling muscle. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0626 |
en_US |
dc.subject.classification |
Master's Theses no. 0626 |
en_US |
dc.subject.lcsh |
Theses (Master's) |
en_US |
dc.title |
Characterization of skeletal muscle antibodies in patients with Autoimmune rippling muscles and Myasthenia Gravis, by Thomas C. Watkins. |
en_US |
dc.type |
Thesis |
en_US |