dc.contributor.author |
Nanosky-Hughes, Monica L. |
en_US |
dc.contributor.author |
Youngstown State University. Criminal Justice Dept. |
en_US |
dc.date.accessioned |
2011-01-31T14:16:34Z |
|
dc.date.accessioned |
2019-09-08T02:27:40Z |
|
dc.date.available |
2011-01-31T14:16:34Z |
|
dc.date.available |
2019-09-08T02:27:40Z |
|
dc.date.created |
1999 |
en_US |
dc.date.issued |
1999 |
en_US |
dc.identifier.other |
b18283196 |
en_US |
dc.identifier.uri |
http://www.ohiolink.edu/etd/view.cgi?ysu997808502 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1828319 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6090 |
|
dc.description |
vii 75 leaves : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 1999. |
en_US |
dc.description |
Includes bibliographical references (leaves ). |
en_US |
dc.description.abstract |
Vohwinkel's Syndrome is a rare autosomal dominant epidermolytic palmoplantar
keratoderma (EPPK). In 1995, Peris et al described as: 1.) diffuse hyperkeratosis of the
palms of the hands and the soles ofthe feet in which the skin takes on a "honey-comb"
appearance. 2.) "star-fish" shaped keratotic plaques on the dorsal surface of the hands
and feet, the wrists, knees, and elbows. 3.) fibrous constricting bands (pseudoainhum) at
the interphalangeal joints that may eventually lead to autoamputation of that digit. 4.) the
invariable appearance of the disease early in life. 5. )and familial incidence (autosomal
dominant inheritance pattern).
Recently, it was discovered that one of the factors contributing to the disease
was a molecular defect in a single protein located in the cornified cell envelope protein,
termed loricrin (Mastrini, 1996).This defect seemingly impairs the differentiation process
of the epidermal renewal system, by not allowing dead skin to slough off. The defect
also contributes to barrier function impairment, causing affected patients to retain water
in the keratinocytes. It was noted in 1988 by Camisa et al that Vohwinkel's Syndrome
patients had an increased level in serum l3-glucuronidase. l3-glucuronidase is a lysosomal
enzyme known to break down constitutive basement membrane proteins. It has been
found in keratinocytes and Langerhan's cells. This study examined the levels of 13glucuronidase
in epidermal skin punch biopsies, blood serum samples, and urine
specimens from both diseased and non-diseased patients. A quantification of the levels
of the enzyme was performed via a double antibody sandwich ELISA. It was
hypothesized by this study that perhaps the increased levels of l3-glucuronidase was
compensatory for the molecular defect in loricrin. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0628 |
en_US |
dc.subject.classification |
Master's Theses no. 0628 |
en_US |
dc.subject.lcsh |
Theses (Master's) |
en_US |
dc.title |
An examination of the levels of human B-glucuronidase in a Vohwinkel's Syndrome Patient, by Monica L. Nanosky-Hughes. |
en_US |
dc.type |
Thesis |
en_US |