Synthesis and use of dienyl phosphates in the Suzuki coupling /

Abstract

The research presented here is a study of the synthesis of bis(2,2,2-trifluoroethyl) vinyl and dienyl phosphates, and their respective reactivities in two well-known coupling reactions. The required vinyl phosphates can be synthesized by known methods, and this methodology can be extended to dienyl phosphates with only a few slight modifications. Bis(2,2,2-trifluoroethyl) vinyl phosphates are shown to be inadequate starting materials for cross coupling reactions when palladium catalysis is used. Nickel catalysis is shown to be moderately effective as a cross coupling catalyst, providing a methodological basis for the synthesis of new aryl substituted diene systems.