dc.contributor.author |
Barak, Joseph M. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Biology. |
en_US |
dc.date.accessioned |
2011-01-31T14:17:08Z |
|
dc.date.accessioned |
2019-09-08T02:29:36Z |
|
dc.date.available |
2011-01-31T14:17:08Z |
|
dc.date.available |
2019-09-08T02:29:36Z |
|
dc.date.created |
2001 |
en_US |
dc.date.issued |
2001 |
en_US |
dc.identifier |
48646779 |
en_US |
dc.identifier.other |
b18877540 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1887754 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6136 |
|
dc.description |
vi, 60 leaves : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 2001. |
en_US |
dc.description |
Includes bibliographical references (leaves 52-59). |
en_US |
dc.description.abstract |
These experiments were designed to investigate the roles of the
plasma membrane Ca2+pumps in regulating relaxation of CCSM tissue in
vitro.
To distinguish the significant importance of these two plasma
membrane pumps in determining CCSM relaxation, two different
experiments were performed. The first experiment compared the relaxation
of isolated CCSM tissues in Kreb's (control) versus Na+ -reduced solution.
The isolated CCSM tissue was treated with norepinephrine (NE) to stimulate
contraction, and sodium nitroprusside (SNP) to induce relaxation. Percent
relaxation values were then recorded for each group.
This experiment focused on the Na+1 Ca2+exchanger and its effects on
relaxation of the CCSM.
The second experiment compared isolated CCSM tissue in three
different groups of media; Kreb's (control) wi DMSO, carboxyeosin wi
DMSO, and Na+-reduced solution wi carboxyeosin. The drug carboxyeosin
is believed to be an inhibitor of the calmodulin-dependant Ca2+ATPase
pump. Again, the isolated CCSM tissue was treated with NE to initiate
contraction, carboxyeosin was then added to the media, and finally SNP was
given for the CCSM tissue to undergo relaxation. This experiment
examined the effects of inhibiting the calmodulin-dependant Ca2+ATPase
pump on the relaxation of CCSM.
Our results demonstrated that both the Na+ICa2+exchange pump and
the calmodulin-dependant Ca2+ATPase pump play an important role in
mediating relaxation of the CCSM tissue tested with the NO donor, SNP. |
en_US |
dc.description.statementofresponsibility |
by Joseph M. Barak. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0730 |
en_US |
dc.subject.classification |
Master's Theses no. 0730 |
en_US |
dc.subject.lcsh |
Impotence. |
en_US |
dc.subject.lcsh |
Penis--Physiology. |
en_US |
dc.subject.lcsh |
Rats--Physiology. |
en_US |
dc.title |
The role of plasma membrane calcium pumps in regulating relaxation of rat corpus cavernosum smooth muscle in vitro / |
en_US |
dc.type |
Thesis |
en_US |