Mematine HCI and amino-alkyl-cyclohexanes (621,625) inhibit HSV-1 in SK-N-SH neuronal cells /

Abstract

Memantine HCI and a series of amino-alkyl-cyclohexanes (AAC) are NMDA receptor antagonists in neuronal cells. Memantine is structurally similar to amantadine and tromantadine, both of which show anti-HSV properties. The activity of memantine and several other AAC's was evaluated by plaque reduction assay of HSV-l KOS in SKN- SH transformed neuronal cells. Memantine and two of the AAC's (621,625) inhibited the formation of plaques in SK-N-SH. Memantine showed a 85 % decrease in plaque formation at 0.03 mM and an ill 50 of 0.023 mM (Figure 2.1a), compound 621 showed a 100% decrease in plaque formation at 0.05 mM and an ill 50 of 0.008 mM (Figure 2.1b), and compound 625 showed a 70% decrease in plaque formation at 0.55 mM and an ill 50 of 0.120 mM (Figure 2.1c).