The synthesis and use of trifluoroethyl vinyl phosphates as electrophiles in the Susuki coupling reaction /

Abstract

The focus of the research presented here is the synthesis and use of tlifluoroethyl vinyl phosphates as electrophiles in the Suzuki coupling reaction. The first step involves the synthesis of vinyl phosphates with the bis(2,2,2-tritluoroethoxy)phosphinyl group. The cross-coupling reaction of vinyl phosphates with arylboronic acids, using catalytic amounts of Ni(O) and K3P04, in anhydrous toluene provides new methods for the synthesis of aryl-substituted olefins.