dc.contributor.author |
Bowman, Russell A. |
en_US |
dc.date.accessioned |
2011-01-31T14:19:18Z |
|
dc.date.accessioned |
2019-09-08T02:29:08Z |
|
dc.date.available |
2011-01-31T14:19:18Z |
|
dc.date.available |
2019-09-08T02:29:08Z |
|
dc.date.created |
1996 |
en_US |
dc.date.issued |
1996 |
en_US |
dc.identifier |
235467121 |
en_US |
dc.identifier.other |
b17622487 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1762248 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6275 |
|
dc.description |
ix, 52 leaves : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 1996. |
en_US |
dc.description |
Includes bibliographical references (leaf 33). |
en_US |
dc.description.abstract |
The focus of the research presented here is the use of bis (2,2,2trifluoroethoxy)
phosphorochloridate as a new coupling reagent for the synthesis
of peptides. Bis (2,2,2-trifluoroethoxy) phosphorochloridate is modeled after
diethyl phosphorocyanide (DEPC). DEPC converts the carboxyl portion of an
amino acid to an O-acyl phosphate, which acts as a leaving group when attacked
by a good nucleophile such as an amino group from a second amino acid,
resulting in the formation of a peptide. The trifluoroethyl groups would enhance
the electrophilicity of the phosphorus, thus increasing the yield of the
intermediate, O-acyl phosphate, and augment the leaving group ability of the
phosphate moiety in the peptide coupling. |
en_US |
dc.description.sponsorship |
Youngstown State University. Dept. of Chemistry. |
en_US |
dc.description.statementofresponsibility |
by Russell A. Bowman. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0554 |
en_US |
dc.subject.classification |
Master's Theses no. 0554 |
en_US |
dc.subject.lcsh |
Peptides. |
en_US |
dc.title |
Bis (2,2,2-trifluoroethoxy) phosphorochloridate : a new method for the synthesis of peptides |
en_US |
dc.type |
Thesis |
en_US |