Synthesis of N-Glycosides using Azidodeoxysugars

Vicarel, Monica L.

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dc.contributor.author	Vicarel, Monica L.	en_US
dc.date.accessioned	2011-01-31T14:19:26Z
dc.date.accessioned	2019-09-08T02:35:37Z
dc.date.available	2011-01-31T14:19:26Z
dc.date.available	2019-09-08T02:35:37Z
dc.date.created	2006	en_US
dc.date.issued	2006	en_US
dc.identifier.other	b19971278	en_US
dc.identifier.uri	http://jupiter.ysu.edu/record=b1997127	en_US
dc.identifier.uri	http://hdl.handle.net/1989/6277
dc.description	X, 151 leaves ; ill. ; 29 cm.	en_US
dc.description.abstract	The following work includes methods of synthesizing N-glycosides. The main focus is the use of azides synthesized from D-glucose and D-galactose as the precursors for the synthesis of a library of analogs that have an N-glycoside linkage that could potentially be tested for biological activity towards Staphylococcus aureus Type 5 and Type 8 capsular polysaccharides. The chemistry includes a modified Staudinger approach to be used for the synthesis of amides. Also a novel approach for the construction of 1, 2, 3-triazole-linked sugars has been studied. An investigation into one-pot conversion of non-sugar alcohols to the corresponding azides has been carried out as well as the development of chemistry mentioned above using microwave irradiation. Stereoselectivity and regiospecificity in the amide and triazole chemistry will be discussed in detail.	en_US
dc.description.sponsorship	Youngstown State UNiversity. Department of Chemistry	en_US
dc.description.statementofresponsibility	by Monica L. Vicarel	en_US
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	Master's Theses no. 0927	en_US
dc.subject.classification	Master's Theses no. 0927	en_US
dc.subject.lcsh	Glycosides.	en_US
dc.subject.lcsh	Chemistry, Organic.	en_US
dc.subject.lcsh	Staphylococcus aureus.	en_US
dc.subject.lcsh	Staphylococcus aureus infections--Prevention.	en_US
dc.title	Synthesis of N-Glycosides using Azidodeoxysugars	en_US
dc.type	Thesis	en_US

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