dc.contributor.author |
Cutrone, Rochelle Marie. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Chemistry. |
en_US |
dc.date.accessioned |
2011-01-31T14:20:43Z |
|
dc.date.accessioned |
2019-09-08T02:30:01Z |
|
dc.date.available |
2011-01-31T14:20:43Z |
|
dc.date.available |
2019-09-08T02:30:01Z |
|
dc.date.created |
1999 |
en_US |
dc.date.issued |
1999 |
en_US |
dc.identifier.other |
b18380633 |
en_US |
dc.identifier.uri |
http://www.ohiolink.edu/etd/view.cgi?ysu998684385 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1838063 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6349 |
|
dc.description |
ix, 51 leaves ; ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 1999. |
en_US |
dc.description |
Includes bibliographical references (leaves ). |
en_US |
dc.description.abstract |
Evidence has shown that intracellular calcium must be elevated in order for secretion of
the granular contents within mast cells to occur. Exogenous nitric oxide (NO) has the
effect of dampening the secretory responses of mast cells while the inhibition of nitric
oxide synthase (NOS) amplifies the secretion. As elevation of intracellular calcium
concentration is essential for secretion to occur, it is likely that NO inhibits secretion by
activating calcium pumps leading to the removal of calcium from the cytosol. This
research examines the role of nitric oxide in the regulation of antigen-activated RBL-2H3
mucosal mast cells and looks to determine which parts of the signal transduction pathway
are involved in the activation and regulation of NO biosynthesis. Knowing that the NOproducing
enzyme, nitric oxide synthase (NOS), is regulated by intracellular calcium, we
will investigate whether a change in nitric oxide production affects intracellular calcium
signals. |
en_US |
dc.description.statementofresponsibility |
by Rochelle Marie Cutrone. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0644 |
en_US |
dc.subject.classification |
Master's Theses no. 0644 |
en_US |
dc.subject.lcsh |
Theses (Master's) |
en_US |
dc.title |
Effect of Nitric Oxide Reagents on intracellular calcium signaling in RBL-2H3 mucosal mast cells, / |
en_US |
dc.type |
Thesis |
en_US |