A study of cell fusion and possible genetic recombination in the parasitic protozoan Leishmania

Martin, Tricia I.

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dc.contributor.author	Martin, Tricia I.
dc.contributor.other	Youngstown State University, degree granting institution.
dc.contributor.other	Youngstown State University. Department of Biology.
dc.date.accessioned	2021-04-26T15:31:26Z
dc.date.available	2021-04-26T15:31:26Z
dc.date.issued	1993
dc.identifier.other	B22675656
dc.identifier.other	1197981390
dc.identifier.uri	https://jupiter.ysu.edu:443/record=b2267565
dc.identifier.uri	http://hdl.handle.net/1989/16200
dc.description	vi, 73 leaves : illustrations ; 29 cm M.S. Youngstown State University 1993. Includes bibliographical references (leaves 68-73).	en_US
dc.description.abstract	Microspectrophotometric quantitative DNA measurements were made on cells of the promastigote stage and the amastigote stage of species in the genus "Leishmania," for the purpose of determining the period of the life cycle where a ploidy change may occur. The results of this study indicate that cellular fusion occurs during the amastigote stage in the genus "Leishmania." These may subsequently undergo mitotic division, while the promastigotes exhibited an accelerated growth stage followed by mitosis, but no cell fusion. Mitosis and cell fusion are the amastigotes occurs within the macrophage cell. Results also indicate that cell fusion increases with the duration of infection in the macrophages. Cell fusion, rather than a single cell doubling its own DNA, is confirmed in isozyme data from what appears to be hybrid isolates of "L. panamensis" and "L. braziliensis." Cell fusion in the amastigote presents a possible mechanism for genetic exchange.	en_US
dc.description.sponsorship	Youngstown State University. Department of Biology.	en_US
dc.language.iso	en_US	en_US
dc.publisher	[Youngstown, Ohio] : Youngstown State University, 1993.	en_US
dc.relation.ispartofseries	Master's Theses;no. 0481
dc.subject	Leishmania.	en_US
dc.subject	Cell hybridization.	en_US
dc.subject	DNA -- Analysis.	en_US
dc.title	A study of cell fusion and possible genetic recombination in the parasitic protozoan Leishmania	en_US
dc.type	Thesis	en_US

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