Formation of N-acetyl-L-fucosamine (L-FucNAc) and analogs as potential inhibitors of Staphylococcus aureus capsular polysaccharide biosynthesis

Alhassan, Abdul-Basit.

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dc.contributor.author	Alhassan, Abdul-Basit.
dc.contributor.other	Youngstown State University. Department of Chemistry.
dc.date.accessioned	2021-06-17T17:14:36Z
dc.date.available	2021-06-17T17:14:36Z
dc.date.issued	2006
dc.identifier.other	B19864449
dc.identifier.other	74163026
dc.identifier.uri	https://jupiter.ysu.edu:443/record=b1986444
dc.identifier.uri	http://hdl.handle.net/1989/16342
dc.description	xiv, 344 leaves : ill. ; 29 cm. Thesis (M.S.)--Youngstown State University, 2006. Includes bibliographical references (leaves 119-124).	en_US
dc.description.abstract	The following piece of work describes the synthesis of N-acety-L-fucosamine (L-FucNAc) and related novel N-glycosides to serve as glycomimetics for the inhibition of Staphylococcus aureus capsular polysaccharide biosynthesis. N-glycosyl amides were made via a modified Staudinger reaction while 1, 4-disubstituted-1,2,3-triazoles were synthesized using 1,3-dipolar cycloaddition of azides to alkynes in the presence of Cu(I) catalyst generated in situ as a a reaction between CuSO4 and Vitamin C.	en_US
dc.description.sponsorship	Youngstown State University. Department of Chemistry.	en_US
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	Master's Theses;no. 0913
dc.subject	Staphylococcus aureus.	en_US
dc.subject	Staphylococcus aureus infections -- Prevention.	en_US
dc.subject	Biomimetics.	en_US
dc.subject	Glycosides.	en_US
dc.title	Formation of N-acetyl-L-fucosamine (L-FucNAc) and analogs as potential inhibitors of Staphylococcus aureus capsular polysaccharide biosynthesis	en_US
dc.type	Thesis	en_US

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