Towards glycomimetic derivatives of N-acetyl-D-fucosamine

Abstract

The following work describes an attempted synthesis towards marking N-Acetyl-D-Fucosamine from N-Acetyl-D-DGluosamine. The bacterium Staphylococcus aureus depends on a capsular polysaccharide to protect it from being destroyed by the body's immune defense system. Thus, if the rare sugar N-Acetyl-D-Fucosamine can be made, more experiment can be done to make small molecule glycomimetics that will possibly inhibit capsular polysaccharide formation.