Investigation of the iso-orotate decarboxylation reaction mechanism : enzymatic and non-enzymatic and study of the isotope effects involved in its mechanism

Potula, Umakanth

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dc.contributor.author	Potula, Umakanth
dc.contributor.other	Youngstown State University. Department of Chemistry.
dc.date.accessioned	2021-06-30T16:38:37Z
dc.date.available	2021-06-30T16:38:37Z
dc.date.issued	2006
dc.identifier.other	B19928233
dc.identifier.other	124040916
dc.identifier.uri	https://jupiter.ysu.edu:443/record=b1992823
dc.identifier.uri	http://hdl.handle.net/1989/16364
dc.description	xiii, 66 leaves : ill. ; 29 cm. Thesis (M.S.)--Youngstown State University, 2006. Includes bibliographical references (leaf 66).	en_US
dc.description.abstract	Some organisms, such as Neurospora crassa, have a unique capability of producing uracil through the thymine salvage pathway. The enzyme involved in the final step of this pathway, Iso-orotate decarboxylase, catalyzes conversion of Iso-orotate to uracil through a decarboxylation reaction. The project done in the lab mainly concentrated on kinetic studies on the non-enzymatic conversion of Iso-orotate to uracil. Apart from this isotope effects involved in the reaction have also been studied to get a comprehensive understanding on the mechanistic details involved in the decarboxylation reaction catalyzed by Iso-orotate decarboxylase. This work will provide a foundation for future mechanistic studies with the enzyme.	en_US
dc.description.sponsorship	Youngstown State University. Department of Chemistry.	en_US
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	Master's Theses;no. 0930
dc.subject	Reaction mechanisms (Chemistry)	en_US
dc.subject	Decarboxylation.	en_US
dc.subject	Decarboxylases.	en_US
dc.subject	Uracil.	en_US
dc.title	Investigation of the iso-orotate decarboxylation reaction mechanism : enzymatic and non-enzymatic and study of the isotope effects involved in its mechanism	en_US
dc.type	Thesis	en_US

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