dc.contributor.author |
Powell, David T. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Biology. |
en_US |
dc.date.accessioned |
2011-01-31T14:17:20Z |
|
dc.date.accessioned |
2019-09-08T02:27:44Z |
|
dc.date.available |
2011-01-31T14:17:20Z |
|
dc.date.available |
2019-09-08T02:27:44Z |
|
dc.date.created |
2000 |
en_US |
dc.date.issued |
2000 |
en_US |
dc.identifier |
44872306 |
en_US |
dc.identifier.other |
b18617232 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1861723 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6148 |
|
dc.description |
1 v. (various pagings) : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 2000. |
en_US |
dc.description |
Includes bibliographical references (leaves 48-56). |
en_US |
dc.description.abstract |
This study was designed to investigate the relative importance of the
intracellular and extracellular calcium stores in mediating the contraction
and relaxation of corporal cavemosal smooth muscle (CCSM) tissues. This
study also investigated the effects of androgens on the calcium pump
mechanism(s) responsible for the relaxation of this tissue.
To determine the relative importance of the intracellular and
extracellular calcium stores in CCSM relaxation, isolated CCSM tissues
were treated with cyclopanazoic acid (CPA) or DMSO (control) before
being contracted by norepinepherine (NE). Sodium nitroprusside (SNP) was
then added to the tissues to induce relaxation. Finally, percent relaxations
were recorded for each group.
The effects of androgens on the calcium pump mechanism(s)
responsible for CCSM relaxation were studied by dividing rats into intact,
castrate, and testosterone replacement treatment groups. Isolated CCSM
tissues were placed in calcium free media and treated with CPA. Next,
CCSM contractions were induced by the addition ofNE and CaCh to the
media. SNP was then added to the media to induce relaxation. Again,
percent relaxations were recorded for each group.
Results from this study indicate that the most important mechanism
responsible for the removal of cytosolic calcium from CCSM is located on
the plasma membrane. This study also shows that castration significantly
reduces the relaxation ofCCSM, presumably by affecting the plasma
membrane mechanism(s) responsible for the removal of calcium from the
cytosol. Testosterone replacement was able to restore CCSM relaxation to
normal levels. These results indicate that the calcium regulating mechanism
utilized by CCSM is, to some extent, androgen regulated. |
en_US |
dc.description.statementofresponsibility |
by David T. Powell. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0687 |
en_US |
dc.subject.classification |
Master's Theses no. 0687 |
en_US |
dc.subject.lcsh |
Impotence. |
en_US |
dc.subject.lcsh |
Penis--Physiology. |
en_US |
dc.title |
Effects of androgen on corpus cavernosum : role of the plasma membrane calcium pumps / |
en_US |
dc.type |
Thesis |
en_US |