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.............................................................................................................x      CHAPTER 1 INTRODUCTION ....................................................................................1 /DERQFKLSDQGLWVDSSOLFDWLRQ 0RGHVRIIORZPRWLRQLQPLFURIOXLGLFFKLSV )XQGDPHQWDOVRIHOHFWURNLQHWLFIORZ (OHFWURRVPRVLV  (OHFWURSKRUHVLV (OHFWULF'RXEOH/D\HU ('/  0RGHOLQJRIHOHFWURNLQHWLFIORZ $QDO\VLVRIHOHFWURNLQHWLF)ORZ 7VKDSHGPLFURIOXLGLFFKLS 2EMHFWLYHVRIWKHVLV 2UJDQL]DWLRQRIWKHVLV    CHAPTER 2 MODELING AND VALIDATION OF ELECTROKINETIC FLOW IN MICROFLUIDIC CHIPS .............12  *HRPHWULFDOPRGHOLQJ 0DWKHPDWLFDOPRGHOLQJ 3UREOHPVHWXSLQ&2062/0XOWLSK\VLFV 1XPHULFDOPRGHOLQJDQGYDOLGDWLRQ 0XOWLSK\VLFVPHWKRGRORJ\ 6ROYHUYDOLGDWLRQ  CHAPTER 3 ANALYSIS OF ELECTROOSMOTIC FLOW IN MICROFLUIDIC CHIPS ...............................................................39 ,QWURGXFWLRQ 0DWKHPDWLFDOPRGHOLQJ 5HVXOWVDQGGLVFXVVLRQV (IIHFWRIYROWDJHGLIIHUHQFHLQPD[LPXPYHORFLW\ 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&RQFHQWUDWLRQ9VRXWOHWKHLJKWRIDPRGLILHGPLFURIOXLGLFFKLSDW  YDULRXVSRWHQWLDOGLIIHUHQFHVIRUWZRLQOHWVDWFRQVWDQW]HWD  SRWHQWLDORI9                                    [ LIST OF TABLES 7DEOH 6XPPDU\RIYDULRXVPHDQVRIIOXLGSURSXOVLRQ 7DEOH 3K\VLFDOFRQVWDQWVRIVDPSOHDQDO\WHVROXWLRQXVHGLQPLFURFKDQQHOV  7DEOH %RXQGDU\FRQGLWLRQVIRUHOHFWURRVPRWLFIORZXVHGLQPLFURFKKDQHOV  7DEOH %RXQGDU\FRQGLWLRQVIRUHOHFWURRVPRWLFIORZXVHGLQPLFURFKKDQHOV  7DEOH %RXQGDU\FRQGLWLRQVIRUHOHFWURSKRUHWLFIORZXVHGLQPLFURFKKDQHOV 7DEOH %RXQGDU\FRQGLWLRQVIRUHOHFWURSKRUHWLFIORZXVHGLQPLFURFKKDQHOV 7DEOH &2062/PXOWLSK\VLFVVROYHUW\SHVDQGWKHLUXVDJH  7DEOH 3K\VLFDOFRQVWDQWVIRUVDPSOHDQDO\WHVROXWLRQVXVHGLQ&2062/ 0XOWLSK\VLFV6RIWZDUH      CHAPTER 1 INTRODUCTION 1.1 Lab on chip and its applications 5HFHQW\HDUVKDYHZLWQHVVHGVLJQLILFDQWDGYDQFHVLQWKHPLFURIOXLGLFVILHOGDQGKDYHVHHQ GHFHQWGHYHORSPHQWRQ/DERQFKLS /2& WHFKQRORJLHVIRUDQXPEHURIELRFKHPLFDO DQDO\VLV/DERQFKLSGHYLFHVSURPLVHPDQ\QRYHODSSOLFDWLRQVFRQFHUQLQJWKHWUDQVSRUW 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