Preliminary Studies on the Effects of Glycosyl Triazoles on C2C12 Stem Cells

Abstract

The C2C12 line of cells differentiates rapidly to form contractile myotubes which give rise to contractile skeletal muscle. The muscle fibers formed from these cells contain a high concentration of glycogen and are heavily reliant on glycolytic enzymes. 1,2,3-triazoles have been shown to have a wide array of biological activities and may mimic peptide bonds or phosphate groups. For this reason it is proposed that glycosyl triazoles may have some effect on the development or function of C2C12 cells as they differentiate.