Abstract:
A new method for the synthesis of bis(2,2,2-trifluoroethyl) [beta]-ketophosphonates from bis(2,2,2-trifluoroethyl) 1-alkynylphosphonates is described herein. Bis(2,2,2-trifluoroethyl) 1-alkynylphosphonates can be treated with primary and secondary amines to prepare enamine vinyl phosphonates. Bis(2,2,2-trifluoroethyl) [beta]-ketophosphonates are obtained after hydrolysis of the enamine vinyl phosphonate.