Synthesis of phosphonopeptide transition state analogs of HIV-1 protease

Lawrence, Kevin A.

Digital.Maag Home
→
Graduate Studies and Research, College of
→
Theses
→
View Item

dc.contributor.author	Lawrence, Kevin A.
dc.contributor.other	Youngstown State University. Department of Chemistry.
dc.date.accessioned	2021-05-05T19:10:34Z
dc.date.available	2021-05-05T19:10:34Z
dc.date.issued	1995
dc.identifier.other	B17307296
dc.identifier.uri	https://jupiter.ysu.edu:443/record=b1730729
dc.identifier.uri	http://hdl.handle.net/1989/16245
dc.description	x, 47 leaves: figures, reference	en_US
dc.description.abstract	A focus of the research presented here is on the multi-step synthesis, isolation and characterization of phosphorous containing transition state analogs. Several procedures for the synthesis of the aminophosphonate core structure and side chain dipeptides were explored. These structures were designed to mimic the tetrahedral intermediate formed during the protease catalyzed hydrolysis of polypeptide substrates. As such, they are potential inhibitors of the HIV-1 protease enzyme.	en_US
dc.description.sponsorship	Youngstown State University. Department of Chemistry.	en_US
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	Master's Theses;no. 0533
dc.title	Synthesis of phosphonopeptide transition state analogs of HIV-1 protease	en_US
dc.type	Thesis	en_US

Files in this item

Name: 533 LawernceThesis.pdf

Size: 10.41Mb

Format: PDF

View/Open

This item appears in the following Collection(s)

Theses

Show simple item record

Search Digital.Maag

Advanced Search

Browse

All of Digital.Maag
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

My Account

Digital.Maag is an archival repository for Youngstown State University. The University Archives makes digital files available to improve access to historical materials and disseminate the intellectual output of Youngstown State University.

Content may be used for teaching, research, and educational purposes. Organizations and individuals seeking to use content for commercial purposes must obtain permission directly from the appropriate copyright holder. Any materials used from this online collection must include a complete acknowledgment, including the name of the collection and a credit line to the Youngstown State University Archives.

Submissions are approved for inclusion in the repository by the University Archives based on several attributes including their relation to the mission of Digital.Maag, technical requirements, and copyright. The content of submissions is considered final. Only University Archives staff may update record descriptions.

Notice and Procedures for Making Claims of Copyright or Intellectual Property Infringement

If you believe that your work has been included in this repository in a way that might constitute copyright infringement, or your intellectual property rights may have been otherwise violated, please provide the University Archives a Notice containing the following information:

Your address, telephone number, and email address;
A description of the copyrighted work that you claim has been infringed;
A description of where the alleged infringing material is located;
A statement by you that you have a good faith belief that the disputed use is not authorized by you, the copyright owner, its agent, or the law;
An electronic or physical signature of the person authorized to act on behalf of the owner of the copyright interest; and
A statement by you, made under penalty of perjury, that the above information is accurate and that you are the copyright owner or authorized to act on behalf of the copyright owner.

University Archives, Maag Library
Youngstown State University
1 University Plaza
Youngstown, OH 44555
archives@ysu.edu