Studies towards a scalable synthesis of N-acetyl-L-fucosamine

Conway, Ryan P.

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dc.contributor.author	Conway, Ryan P.
dc.contributor.other	Youngstown State University. Department of Chemistry.
dc.date.accessioned	2021-10-14T17:36:26Z
dc.date.available	2021-10-14T17:36:26Z
dc.date.issued	2007
dc.identifier.other	B20213979
dc.identifier.other	190693639
dc.identifier.uri	https://jupiter.ysu.edu:443/record=b2021397
dc.identifier.uri	http://hdl.handle.net/1989/16626
dc.description	xii, 241 leaves : ill. ; 29 cm. Thesis (M.S.)--Youngstown State University, 2007. Includes bibliographical references (leaves 78-80).	en_US
dc.description.abstract	The following describes two attempted syntheses of the rare sugar N-acetyl-L-fucosamine (L-FucNAc) from the inexpensive and readily available L-rhamnose. The syntheses will each involve a protection, oxidation, and reduction strategy in the inversion of the stereochemistry about two sterocenters in L-rhamnose, as well as the introduction of nitrogen at the C-2 position. N-Acetyl-L-fucosamine is one of three carboydrate components of the capsular polysaccharide (CP) of Staphylococcus aureus, which protects the bacterium from the body's immune response. The termination of the CP may provide alternative therapies against S. aureus and possibly other pathogens.	en_US
dc.description.sponsorship	Youngstown State University. Department of Chemistry.	en_US
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	Master's Theses;no. 0963
dc.subject	Staphylococcus aureus infections -- Prevention.	en_US
dc.subject	Sugars.	en_US
dc.subject	Carbohydrates -- Synthesis.	en_US
dc.title	Studies towards a scalable synthesis of N-acetyl-L-fucosamine	en_US
dc.type	Thesis	en_US

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