Formation of glycomimetics of n-acetyl-d-glucosamine, n-acetyl-d-quinavosamine, and n-acetyl-d- and l-fucosamine using the nitroglycal method /

Abstract

This project involves the synthesis of amino sugar analogs that may potentially inhibit enzymes that construct the capsular polysaccharide of Staphylococcus aureus bacteria. Specifically, the syntheses of N-acetyl-D-glucosamine, N-acetyl-Dquinavosamine, N-acetyl-D-fucosamine, and N-acetyl-L-fucosamine analogs from readily available precursors were the targets of the research project. Methods and results for the formation of each ofthese compounds are described in detail.