dc.contributor.author |
Andrews, James Arthur. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Biology. |
en_US |
dc.date.accessioned |
2011-01-31T14:17:27Z |
|
dc.date.accessioned |
2019-09-08T02:27:45Z |
|
dc.date.available |
2011-01-31T14:17:27Z |
|
dc.date.available |
2019-09-08T02:27:45Z |
|
dc.date.created |
2000 |
en_US |
dc.date.issued |
2000 |
en_US |
dc.identifier |
44865922 |
en_US |
dc.identifier.other |
b18617244 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1861724 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6149 |
|
dc.description |
1 v. (various pagings) : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 2000. |
en_US |
dc.description |
Includes bibliographical references (leaves 82-97). |
en_US |
dc.description.abstract |
Clinical evidence has shown estrogen may delay the onset of
Alzheimer's disease and protect against neuronal damage associated with
stroke. Intracellular recordings (current-clamp) were made to characterize
the effects of estrogen in the basolateral amygdala (BLA) of the rat brain.
Excitatory postsynaptic potentials (EPSPs) were elicited by stimulation of
afferents in the external capsule. Estrogen was found to decrease EPSP
amplitude in a rapid (20-30 min) fashion. Similarly, reduction of
spontaneous synaptic activity occurred upon estrogen treatment. EPSP
amplitudes returned to normal within 20 minutes of estrogen washout. 4hydroxy
tamoxifen (4-0HT), and estrogen receptor antagonist, prevented the
estrogen-induced decrease in EPSP amplitude, suggesting dependence on an
estrogen receptor. Estrogen treatment had no effect on neuronal input
resistance, accommodation response, resting membrane potential, or action
potential firing frequency. Preliminary data showed no change in inhibitory
postsynaptic potential (IPSP) amplitude, suggesting estrogen might act on
the presynaptic cell. These findings imply that estrogen may be protecting
neurons from excitotoxic injury associated with stroke through the
modulation of glutamate release. |
en_US |
dc.description.statementofresponsibility |
by James Arthur Andrews. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0689 |
en_US |
dc.subject.classification |
Master's Theses no. 0689 |
en_US |
dc.subject.lcsh |
Alzheimer's disease--Treatment. |
en_US |
dc.subject.lcsh |
Estrogen--Therapeutic use. |
en_US |
dc.subject.lcsh |
Amygdaloid body--Effect of chemicals on. |
en_US |
dc.title |
Effects of estrogen in the basolateral amygdala of the rat brain / |
en_US |
dc.type |
Thesis |
en_US |