dc.contributor.author |
Caplinger, John N. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Chemistry. |
en_US |
dc.date.accessioned |
2011-01-31T14:17:33Z |
|
dc.date.accessioned |
2019-09-08T02:29:17Z |
|
dc.date.available |
2011-01-31T14:17:33Z |
|
dc.date.available |
2019-09-08T02:29:17Z |
|
dc.date.created |
2001 |
en_US |
dc.date.issued |
2001 |
en_US |
dc.identifier |
47280342 |
en_US |
dc.identifier.other |
b18796874 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1879687 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6156 |
|
dc.description |
viii, 66 leaves : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 2001. |
en_US |
dc.description |
Includes bibliographical references. |
en_US |
dc.description.abstract |
Memantine HCI and a series of amino-alkyl-cyclohexanes (AAC) are NMDA
receptor antagonists in neuronal cells. Memantine is structurally similar to amantadine
and tromantadine, both of which show anti-HSV properties. The activity of memantine
and several other AAC's was evaluated by plaque reduction assay of HSV-l KOS in SKN-
SH transformed neuronal cells. Memantine and two of the AAC's (621,625) inhibited
the formation of plaques in SK-N-SH. Memantine showed a 85 % decrease in plaque
formation at 0.03 mM and an ill 50 of 0.023 mM (Figure 2.1a), compound 621 showed a
100% decrease in plaque formation at 0.05 mM and an ill 50 of 0.008 mM (Figure 2.1b),
and compound 625 showed a 70% decrease in plaque formation at 0.55 mM and an ill 50
of 0.120 mM (Figure 2.1c). |
en_US |
dc.description.statementofresponsibility |
by John N. Caplinger. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0708 |
en_US |
dc.subject.classification |
Master's Theses no. 0708 |
en_US |
dc.subject.lcsh |
Herpes simplex virus. |
en_US |
dc.subject.lcsh |
Neurons. |
en_US |
dc.title |
Mematine HCI and amino-alkyl-cyclohexanes (621,625) inhibit HSV-1 in SK-N-SH neuronal cells / |
en_US |
dc.type |
Thesis |
en_US |