Synthesis of bis(2,2,2-trifluoroethyl) phosphonoalkynes /

Abstract

The focus of this research was a nucleophilic substitution of l-alkynyl anions with bis(2,2,2-trifluoroethyl)phosphorochloridate as the electrophilic center. From this research, we have achieved a greater understanding of the chemistry of nucleophilic carbon on highly electrophilic phosphorus and how the reaction can be performed to favor the monosubstituted bis(2,2,2-trifluoroethyl)phosphonoalkyne product in moderate to good yields.