dc.contributor.author |
Zelinka, Liza M. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Biology. |
en_US |
dc.date.accessioned |
2011-01-31T14:18:23Z |
|
dc.date.accessioned |
2019-09-08T02:30:27Z |
|
dc.date.available |
2011-01-31T14:18:23Z |
|
dc.date.available |
2019-09-08T02:30:27Z |
|
dc.date.created |
2002 |
en_US |
dc.date.issued |
2002 |
en_US |
dc.identifier |
51181667 |
en_US |
dc.identifier.other |
b19012494 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1901249 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6207 |
|
dc.description |
vii, 60 leaves : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 2002. |
en_US |
dc.description |
Includes bibliographical references (leaves 55-60). |
en_US |
dc.description.abstract |
Rippling muscle disease was first characterized by Torbergsen et al. in 1975. The
rippling phenomena were described as stretch and percussion activated wave like
contractions, that roll through the large skeletal muscles of the body. These muscle
"ripples" appeared to be electrically silent (showing no motor unit action potentials). This
disorder has been shown to be autosomal dominant and heterogenetic (Ricker et al.,
1989). In 1996 Dr. Carl Ansevin described a patient who exhibited rippling phenomena
without any family history of neuromuscular disorder. The patient's rippling muscles
were associated with the onset of myasthenia gravis and both disorders were effectively
treated with immunosuppressive therapies. This led to the assertion that one form of
rippling muscles is related to an autoimmune response to stretch activated ca2+ channels
(Ansevin et al., 1996). Our lab has shown that there are autoantibodies to high and very
high molecular weight proteins in skeletal muscle, this immunoreactivity is not shown in
patients with myasthenia gravis alone. Our lab has also demonstrated that rippling muscle
patients also have autoantibodies to native proteins of very high molecular weight by
immunoprecipitation from skeletal muscle (Walker et al., 1999). This project describes
the cellular localization of rippling muscle autoantigen. Immunocytochemistry with
cultured skeletal muscle myocytes show autoantibody reactivity with components of the
T-tubular region of skeletal muscle. |
en_US |
dc.description.statementofresponsibility |
by Lisa M. Zelinka. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0759 |
en_US |
dc.subject.classification |
Master's Theses no. 0759 |
en_US |
dc.subject.lcsh |
Muscles--Diseases. |
en_US |
dc.subject.lcsh |
Musculoskeletal system. |
en_US |
dc.title |
The immunofluorescent localization of antigens associated with autoimmune rippling muscles / |
en_US |
dc.type |
Thesis |
en_US |