dc.contributor.author |
Saleh, Samer Mohammed. |
en_US |
dc.contributor.author |
Youngstown State University. Dept. of Biology. |
en_US |
dc.date.accessioned |
2011-01-31T14:20:26Z |
|
dc.date.accessioned |
2019-09-08T02:34:56Z |
|
dc.date.available |
2011-01-31T14:20:26Z |
|
dc.date.available |
2019-09-08T02:34:56Z |
|
dc.date.created |
2003 |
en_US |
dc.date.issued |
2003 |
en_US |
dc.identifier.other |
b19608275 |
en_US |
dc.identifier.uri |
http://jupiter.ysu.edu/record=b1960827 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/1989/6328 |
|
dc.description |
vii, 66 leaves : ill. ; 29 cm. |
en_US |
dc.description |
Thesis (M.S.)--Youngstown State University, 2003. |
en_US |
dc.description |
Includes bibliographical references (leaves 58-65). |
en_US |
dc.description.abstract |
This thesis examined the relationship between the presence or the absence of
testosterone on the function of the dopamine transporter system (DAT) in adult male rats.
Eighteen male rats were assigned to control, castrated (GNX), and castrated with
testosterone replacement (GNX+T) groups. Using an in vitro superfusion technique, the
corpus striatum from each rat was divided and treated with dopamine, MPP+, and NMF
infusions. Striatal dopamine and DOPAC levels were measured during baseline
conditions and after drug infusion. Results of our experiments demonstrated that
dopamine and DOPAC recovery were greatest in the GNX rats and were decreased in the
intact or the GNX+T animals. Testosterone appears to be an important steroid that
modulates the function of the DAT. Testosterone acts to enhance DAT activity while the
loss of testosterone reduces DAT function. With respect to activity of neurotoxins (such
as MPP+) to cause symptoms of PD, our results suggest that men may be more prone to
this disease due to the facilitatory actions of testosterone on the DAT activity. Further
experiments are needed to examine in detail the mechanisms of action of testosterone on
DAT function and to explore the relationship DAT function and neurodegenerative
diseases. |
en_US |
dc.description.statementofresponsibility |
by Samer Mohammed Saleh. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.relation.ispartofseries |
Master's Theses no. 0800 |
en_US |
dc.subject.classification |
Master's Theses no. 0800 |
en_US |
dc.subject.lcsh |
Dopamine. |
en_US |
dc.subject.lcsh |
Parkinson's disease. |
en_US |
dc.title |
Androgen modulation of dopamine transporter function in the corpus striatum of male rats / |
en_US |
dc.type |
Thesis |
en_US |