Effect of Nitric Oxide Reagents on intracellular calcium signaling in RBL-2H3 mucosal mast cells, /

Cutrone, Rochelle Marie.; Youngstown State University. Dept. of Chemistry.

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dc.contributor.author	Cutrone, Rochelle Marie.	en_US
dc.contributor.author	Youngstown State University. Dept. of Chemistry.	en_US
dc.date.accessioned	2011-01-31T14:20:43Z
dc.date.accessioned	2019-09-08T02:30:01Z
dc.date.available	2011-01-31T14:20:43Z
dc.date.available	2019-09-08T02:30:01Z
dc.date.created	1999	en_US
dc.date.issued	1999	en_US
dc.identifier.other	b18380633	en_US
dc.identifier.uri	http://www.ohiolink.edu/etd/view.cgi?ysu998684385	en_US
dc.identifier.uri	http://jupiter.ysu.edu/record=b1838063	en_US
dc.identifier.uri	http://hdl.handle.net/1989/6349
dc.description	ix, 51 leaves ; ill. ; 29 cm.	en_US
dc.description	Thesis (M.S.)--Youngstown State University, 1999.	en_US
dc.description	Includes bibliographical references (leaves ).	en_US
dc.description.abstract	Evidence has shown that intracellular calcium must be elevated in order for secretion of the granular contents within mast cells to occur. Exogenous nitric oxide (NO) has the effect of dampening the secretory responses of mast cells while the inhibition of nitric oxide synthase (NOS) amplifies the secretion. As elevation of intracellular calcium concentration is essential for secretion to occur, it is likely that NO inhibits secretion by activating calcium pumps leading to the removal of calcium from the cytosol. This research examines the role of nitric oxide in the regulation of antigen-activated RBL-2H3 mucosal mast cells and looks to determine which parts of the signal transduction pathway are involved in the activation and regulation of NO biosynthesis. Knowing that the NOproducing enzyme, nitric oxide synthase (NOS), is regulated by intracellular calcium, we will investigate whether a change in nitric oxide production affects intracellular calcium signals.	en_US
dc.description.statementofresponsibility	by Rochelle Marie Cutrone.	en_US
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	Master's Theses no. 0644	en_US
dc.subject.classification	Master's Theses no. 0644	en_US
dc.subject.lcsh	Theses (Master's)	en_US
dc.title	Effect of Nitric Oxide Reagents on intracellular calcium signaling in RBL-2H3 mucosal mast cells, /	en_US
dc.type	Thesis	en_US

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